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| » 작성자 : 장경수 | » 작성일 : 2013-10-21 | » 조회 : 1118 |
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| 회원님들.. 대한의생명과학회 2013년 춘계심포지움 초록양식을 첨부하여 공지합니다. 많은 투고 부탁드립니다. 학회가 발돋움하고 있으며 회원님들 덕분에 내년에 더욱 성장하리가 믿습니다. 회원님들의 건승을 기원합니다. 대한의생명과학회 학술위원회 <2013년도 대한의생명과학회 초록 예시-전체 줄간격 160%> 초록 제목: 신명조 13 point 굵은글씨 Tumor-specific delivery of anti-tumoral siRNA using EGF-receptor aptamer-conjugated nanoparticles 저자: 신명조 11 point, 모든 저자의 소속을 윗첨자로 표시 Hwa Yeon Jeong1, Yeon Kyung Lee1, Jung Seok Kim1, Seong Jae Kang1, Min Woo Kim1, Hong Sung Kim2, Keun Sik Kim3, Yong Serk Park1 저자 소속: 신명조 10 point 이탤릭체, 기관명 앞에 윗첨자 표시 1Dept. of Biomedical Laboratory Science, Yonsei University, Wonju 220-710 2Dept. of Biomedical Laboratory Science, Korea Nazarene University, Cheonan 331-718 3Dept. of Biomedical Laboratory Science, Konyang University, Daejeon 302-718, Republic of Korea 초록 본문: 신명조 10 point, 20줄 이내 The most important consideration in cancer therapy is the tumor-specific delivery of therapeutic agents such as chemical drugs and gene medicines. It is necessary to use an efficient delivery system to enhance drug delivery to intended cells and reduce side effects of cytotoxic agents. In this study, a cancer-specific aptamer was adopted for cancer-directed delivery of nanoparticles containing anti-cancer siRNAs. Aptamers made of nucleic acids have been developed to have targeting capability to certain specific molecules with strong physical stability. In addition, they are smaller and less immunogenic compared to antibody molecules. Aptamer-conjugated liposomes exhibited a tumor-specific binding and delivery capability. To prove a potential application of aptamer-conjugated liposomes in cancer therapy, anti-EGFR aptamers were conjugated to liposomal nanoparticles encapsulating anti-tumoral siRNA and then compared to anti-EGFR antibody (cetuximab)-conjugated liposomes in terms of tumor-specific binding and siRNA delivery. A431 cells (EGFR-positive) and HepG2 cells (EGFR-negative) were transfected with the two different systems and then analyzed by confocal microscopy and FACS. This investigation suggests that aptamer-conjugated liposomal nanoparticles can be utilized as an alternative system for tumor-directed delivery of therapeutic genes. 연구비지원 명시: 신명조 10 point Supported by the Brain Korea 21 Project for Medical Science, Yonsei University Key words 명시: 신명조 10 point, 4개 이상 Key words: cancer therapy, EGFR, aptamer, siRNA, liposome, nanoparticle |
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